Associate Professor TUMS Iran
Title: Nanoparticles as new tools for inhibition of cancer angiogenesis
Babak Negahdari has his expertise in medical biotechnology and nanotechnology. His experimental projects are based on application of nanotechnology and biotechnology in life improving of cancer patients and their therapeutic applications.
Angiogenesis is known as one of the hallmarks of cancer. Multiple lines evidence indicated that vascular endothelium growth factor (VEGF) is a key player in the progression of angiogenesis and exerts its functions via interaction with tyrosine kinase receptors (TKRs). These receptors could trigger a variety of cascades that lead to the supply of oxygen and nutrients to tumor cells and survival of these cells. With respect to pivotal role of angiogenesis in the tumor growth and survival, finding new therapeutic approaches via targeting angiogenesis could open a new horizon in cancer therapy. Among various types of therapeutic strategies, nanotechnology has emerged as new approach for the treatment of various cancers. Nanoparticles (NPs) could be used as effective tools for targeting a variety of therapeutic agents. According to in vitro and in vivo studies, NPs are efficient in depriving tumor cells from nutrients and oxygen by inhibiting angiogenesis. However, the utilization of NPs are associated with a variety of limitations. It seems that new approaches such as NPs conjugated with hydrogels could overcome to some limitations. In the present review, we summarize various mechanisms involved in angiogenesis, common anti-angiogenesis strategies, and application of NPs for targeting angiogenesis in various cancers.
Recent publications (minimum 5)
1. Nanoceria: a rare-earth nanoparticle as a novel anti-angiogenic therapeutic agent in ovarian cancer. PloS one 8(1):e54578
2. Gurunathan S, Lee K-J, Kalishwaralal K, Sheikpranbabu S, Vaidyanathan R, Eom SH. 2009. Antiangiogenic properties of silver nanoparticles. Biomaterials 30(31):6341-6350.
3. Jin H, Pi J, Yang F, Wu C, Cheng X, Bai H, Huang D, Jiang J, Cai J, Chen ZW. 2016. Ursolic acid-loaded chitosan nanoparticles induce potent anti-angiogenesis in tumor. Applied microbiology and biotechnology 100(15):6643-6652.
4. Hu H, You Y, He L, Chen T. 2015. The rational design of NAMI-A-loaded mesoporous silica nanoparticles as antiangiogenic nanosystems. Journal of Materials Chemistry B 3(30):6338- 6346.
5. Guarnieri D, Malvindi MA, Belli V, Pompa PP, Netti P. 2014. Effect of silica nanoparticles with variable size and surface functionalization on human endothelial cell viability and angiogenic activity. Journal of nanoparticle research 16(2):2229.